Training mental habitutaion
In mundane cases, treatments are focused on gradually training and improving mental habituation to sex and physical development of stimulation control. In clinical cases, various medications are being tested to help slow down the speed of the arousal response.
Start and stop technique
Masters and Johnson recommended a start and stop technique to increase the time till ejaculation. This requires a great deal of couple cooperation and communication, and may be difficult for some.
Control instead of prevention
Another method is that of control instead of prevention. Performing routines such as Kegel exercises, which, as mentioned above, relate to gaining voluntary control of the PC muscle and thus give a person more control over ejaculation. When ejaculating, the control of this muscle is said to be lost, and thus, learning to maintain control of it can be of aid to some.
Medications
Serotonergic medications, such as SSRIs, can delay ejaculation. SSRIs are commonly used as anti-depressants. Examples include Prozac, Zoloft, Celexa, Effexor, and Lexapro. Clinical trials indicate that Paroxetine gives the largest increase in intravaginal ejaculation latency time. Clomipramine often helps with serious cases that are related to the central nervous system (as opposed to psychological factors). The drug has the added benefit of also improving erection quality in some patients.
5-HTP supplements
William Francis Ganong cited dietary 5-HTP as an alternative source to raising serotonin levels. Many supplements are available that contain 5-HTP.
Medical grade topical anesthetics are a common ingredient in many over-the-counter products such as condoms and non-aerosol sprays. Magnesium deficiency, very common in the Western world and especially in the United States, has been associated with premature ejaculation.